NMR spin trapping: Detection of free radical reactions using a phosphorus-containing nitrone spin trap

Nmr and Mri Spin Trapping: Using Nmr to Learn about Free Radical Reactions

The paper supports the idea that NMR spectroscopy and imaging can enhance the classical EPR spin trapping techniques. NMR was used to follow and identify the diamagnetic products of DEPMPO/R• spin adduct breakdown. Oxyradical adducts of DEPMPO led to recycling of the spin trap, however, without sufficient long-term accumulation that would enhance EPR detection in vivo. Fluorinated derivative of...

Phenoxy radical detection using P NMR spin trapping

ion and subsequent deprotonation gives rise to phenoxy radicals, which play a pivotal role in lignin chemistry. Overall spin trapping systems could be powerful tools to understand the radical intermediates involved in lignin chemistry. In Table 4 our data on spin trap experiments with DIPPMPO and different phenols are shown. There are different oxidation systems for the generation of phenoxy ra...

Spin trapping of hydroperoxyl radical by a cyclic nitrone conjugated to β-cyclodextrin: a computational study.

Spin trapping of hydroperoxyl radical (HOO.) by the amide-linked conjugate of 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) to β-cyclodextrin (β-CD) was studied computationally using a two-layered ONIOM method. From a conformational perspective, the "internal" conformation of 5R-β-CD-AMPO is more favored than the "external" conformation in which the nitrone is located outside of the cavity of...

EPR Detection of the Superoxide Free Radical with the Nitrone Spin Traps DMPO and BMPO

acterizing free radicals in chemistry, biology and medicine, is detection by EPR spectroscopy. However, due to their high reactivity and short half-lives, direct EPR detection of many free radicals (e.g., superoxide, hydroxyl radical, alkyl radicals, etc.) is virtually impossible in solution at room temperature. Spin trapping is a technique developed in the late 1960s in which a nitrone or nitr...

Metabolic activation of carbon tetrachloride to a free-radical product: studies using a spin trap.